BACKGROUND This study was carried out to evaluate whether bilateral orchidopexy represents a poor or good prognostic factor in azoospermic men undergoing testicular sperm extraction (TESE). METHODS One hundred and seven presumed non-obstructive azoospermia (NOA) patients, according to conventional clinical parameters (volume of testis, FSH, clinical history) were submitted to testicular biops...

Generation of functional spermatids from azoospermia patients is of unusual significance in the treatment of male infertility. Here, we report an efficient approach to obtain human functional spermatids from cryptorchid patients. Spermatogonia remained whereas meiotic germ cells were rare in cryptorchid patients. Expression of numerous markers for meiotic and postmeiotic male germ cells was enh...

Objective- Release of free radicals and oxidants following increased temperature of testis in cryptorchidism, play an important role in the producing testicular damage. The present study investigated the role of vitamin C as an antioxidant in protecting the testis against damage in experimental unilateral cryptorchidism. Design- Experimental study Animals- Forty five male adult Wistar–Albino ...

BACKGROUND A specific type of partial AZFc deletion, called 'gr/gr' deletion, was recently proposed as genetic risk factor for spermatogenic impairment and testis cancer. Since both pathologies can be part of the testicular dysgenesis syndrome (TDS), we aimed to define the role of 'gr/gr' deletion in the aethiopathogenesis of another component of the TDS: cryptorchidism. METHODS A total of 14...

There are many applications for laparoscopy in small animal surgery. A relatively simple one is abdominal cryptorchid castration. Laparoscopic examination of the peritoneal cavity can both aid in the diagnosis of abdominal cryptorchidism and allow treatment using either a totally laparoscopic or a laparoscopic-assisted technique. Minimally invasive cryptorchid castration obviates the need for "...

Background Infertility affects around 15% of couples, and male factors account for 50%. Cryptorchidism is one of the most common causes for azoospermia. Generation of functional spermatids from azoospermia patients is of unusual significance for treating male infertility. It has been recently reported by peers and us that human spermatogonial stem cells (SSCs) can be clearly identified and cult...

PURPOSE We evaluated the clinical and therapeutic characteristics of adult cryptorchidism, which have been difficult to establish, given the small number of patients presenting to outpatient clinics. MATERIALS AND METHODS A retrospective study of 20 adult patients with cryptorchid testis was performed. We analyzed their palpation of testis, location, surgical method, marital status, number of...

Anti-Müllerian hormone (AMH), a glycoprotein secreted from the fetal testis, is responsible for regression of the Müllerian duct in the male fetus. The aim of this study was to evaluate the usefulness of serum AMH as a biomarker for diagnosis of cryptorchidism in horses. Serum AMH concentrations were measured in intact stallions, hemi-castrated unilateral cryptorchid stallions, and geldings. In...

background: cryptorchidism is a common malformation in neonates; surgery or medical treatments are applied during childhood. untreated cryptorchid testes are in the risk of intratubular germ cell neoplasia (igcn) and consequently invasive testicular tumors which could be shown by immunohistochemistry staining for placental like acid phosphatase (plap) marker. objective: we designed this study t...

PURPOSE We examined the significance of the CAG repeat polymorphism in the pathogenesis of cryptorchidism. MATERIALS AND METHODS Genomic deoxyribonucleic acid (DNA) was extracted from blood samples from 42 cryptorchid boys and from 31 non-cryptorchid control subjects. In the cryptorchid group, 7 had bilateral cryptorchidism and 6 had patent processus vaginalis in the contralateral side. To de...